Abstract
Seven new stigmastane-type steroidal glycosides, vernocuminosides A-G (1-7), have been isolated from the stem barks of Vernonia cumingiana Benth. The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods including 1D and 2D NMR ((1)H-(1)H COSY, HSQC, HMBC, and NOE) experiments, especially the employment of Snatzke's method expressed by the induced circular dichroism spectra. Anti-inflammatory activities and cytotoxicities of compounds 1-7 were evaluated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry*
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology
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Drug Evaluation, Preclinical
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Glucosides / chemistry*
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Glucosides / isolation & purification
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Glucosides / pharmacology
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Glucuronidase / metabolism
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Leukocytes / metabolism
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Plant Stems / chemistry*
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Platelet Activating Factor / biosynthesis
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Rats
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Steroids / chemistry*
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Steroids / isolation & purification
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Steroids / pharmacology
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Vernonia / chemistry*
Substances
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Anti-Inflammatory Agents
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Glucosides
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Platelet Activating Factor
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Steroids
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Glucuronidase