Cathepsin G increases MMP expression in normal human fibroblasts through fibronectin fragmentation, and induces the conversion of proMMP-1 to active MMP-1

J Dermatol Sci. 2009 Feb;53(2):150-2. doi: 10.1016/j.jdermsci.2008.08.006. Epub 2008 Oct 2.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aging
  • Buttocks
  • Cathepsin G
  • Cathepsins / antagonists & inhibitors
  • Cathepsins / metabolism*
  • Cells, Cultured
  • Enzyme Activation
  • Enzyme Precursors / metabolism*
  • Female
  • Fibroblasts / drug effects
  • Fibroblasts / enzymology*
  • Fibroblasts / radiation effects
  • Fibronectins / metabolism*
  • Humans
  • Male
  • Matrix Metalloproteinase 1 / genetics
  • Matrix Metalloproteinase 1 / metabolism*
  • Matrix Metalloproteinase 2 / metabolism
  • Middle Aged
  • Peptide Fragments / metabolism*
  • RNA, Messenger / metabolism
  • Serine Endopeptidases / metabolism*
  • Serine Proteinase Inhibitors / pharmacology
  • Skin / cytology
  • Skin / drug effects
  • Skin / enzymology*
  • Skin / radiation effects
  • Ultraviolet Rays

Substances

  • Enzyme Precursors
  • Fibronectins
  • Peptide Fragments
  • RNA, Messenger
  • Serine Proteinase Inhibitors
  • Cathepsins
  • Serine Endopeptidases
  • CTSG protein, human
  • Cathepsin G
  • MMP2 protein, human
  • Matrix Metalloproteinase 2
  • MMP1 protein, human
  • Matrix Metalloproteinase 1