Abstract
4-Amino-5-phenyl-4H-1,2,4-triazole-3-thiol (1) underwent facile condensation with various phosphorus dichlorides (2a-j) in the presence of triethylamine in dry tetrahydrofuran at 60-65 degrees C and afforded corresponding thiadiazaphosphol-2-ones (3a-j). Their chemical structures were characterized using IR, (1)H-, (13)C-, (31)P-NMR and Mass spectral studies. All the title compounds were screened for antioxidant properties by radical scavenging methods such as 1,1-diphenyl-2-picryl hydrazyl (DPPH), hydroxyl and lipid peroxidation. They exhibited potent in vitro antioxidant activity dose dependently. Their bioassay showed them to possess significant antibacterial activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology*
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Antioxidants / chemical synthesis*
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Antioxidants / pharmacology*
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Ascorbic Acid / chemistry
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Bacteria / drug effects
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Biphenyl Compounds
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Ferric Compounds / chemistry
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Free Radical Scavengers / chemical synthesis
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Free Radical Scavengers / pharmacology
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Hydroxyl Radical / chemistry
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Lipid Peroxidation / drug effects
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Microbial Sensitivity Tests
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Organophosphorus Compounds / chemical synthesis*
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Organophosphorus Compounds / pharmacology*
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Picrates / chemistry
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Spectrophotometry, Infrared
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Thiadiazoles / chemical synthesis*
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Thiadiazoles / pharmacology*
Substances
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Anti-Bacterial Agents
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Antioxidants
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Biphenyl Compounds
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Ferric Compounds
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Free Radical Scavengers
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Organophosphorus Compounds
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Picrates
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Thiadiazoles
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Hydroxyl Radical
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1,1-diphenyl-2-picrylhydrazyl
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Ascorbic Acid