[Chronic effect of thyroxine on behavior and brain serotonin receptors in mice with the sharp difference in predisposition to catalepsy]

Zh Vyssh Nerv Deiat Im I P Pavlova. 2008 Jul-Aug;58(4):493-9.
[Article in Russian]

Abstract

Effects of chronic thyroxine treatment (2mg/l, 60 days) on catalepsy, functional activity and expression of 5-HT(1A) and 5-HT(2A) receptors genes in the brain were studied in adult males of catalepsy-prone ASC and catalepsy-resistant AKR mouse strains. Thyroxine caused an appearance of cataleptics in AKR, but produced an anticataleptic effect on ASC mice. Chronic thyroxine treatment increased the functional activity and expression of 5-HT(2A) receptors in the frontal cortex in AKR, but not in ASC mice. Hormone markedly attenuated hypothermic effect of 8-OH-DPAT, 5-HT(1A) receptor agonist, but did not affect the expression of 5-HT(1A) receptors in ASC mice. The results suggest the involvement of the 5-HT(2A) receptors in the cataleptogenic and the 5-HT(1A) receptors in the anticataleptic effects of hormone.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / drug effects
  • Brain / metabolism*
  • Catalepsy / drug therapy
  • Catalepsy / physiopathology*
  • Frontal Lobe / metabolism
  • Hypothermia, Induced
  • Male
  • Mice
  • Mice, Inbred AKR
  • Receptor, Serotonin, 5-HT1A / metabolism*
  • Receptor, Serotonin, 5-HT2A / metabolism*
  • Serotonin 5-HT1 Receptor Agonists
  • Serotonin 5-HT2 Receptor Agonists
  • Species Specificity
  • Thyroxine / pharmacology*
  • Thyroxine / therapeutic use

Substances

  • Receptor, Serotonin, 5-HT2A
  • Serotonin 5-HT1 Receptor Agonists
  • Serotonin 5-HT2 Receptor Agonists
  • Receptor, Serotonin, 5-HT1A
  • Thyroxine