Abstract
The n-butanol (n-BuOH) fraction of Orostachys japonicus A. Berger (Crassulaceae) significantly inhibited calpain activity. Through the activity-guided isolation from the n-BuOH fraction, herbacetin 8-O-alpha-D-ribopyranoside (1), kaempferol (2), quercetin (3), afzelin (4), astragalin (5), isoquercetin (6) and quercitrin (7) were obtained. Their structures were determined by spectroscopic techniques. Among them, compound 3 and 5 had significant calpain inhibitory activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Butanol / chemistry
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Calpain / antagonists & inhibitors*
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Calpain / metabolism
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Crassulaceae / chemistry*
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Cysteine Proteinase Inhibitors / chemistry
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Cysteine Proteinase Inhibitors / isolation & purification*
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Cysteine Proteinase Inhibitors / pharmacology*
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Flavonoids / chemistry
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Flavonoids / isolation & purification*
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Flavonoids / pharmacology*
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Kaempferols / chemistry
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Kaempferols / isolation & purification
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Kaempferols / pharmacology
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / isolation & purification
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Neuroprotective Agents / pharmacology
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Quercetin / chemistry
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Quercetin / isolation & purification
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Quercetin / pharmacology
Substances
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Cysteine Proteinase Inhibitors
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Flavonoids
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Kaempferols
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Neuroprotective Agents
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Plant Extracts
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1-Butanol
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Quercetin
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astragalin
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Calpain