T(peak)T(end) interval in long QT syndrome

J Electrocardiol. 2008 Nov-Dec;41(6):603-8. doi: 10.1016/j.jelectrocard.2008.07.024. Epub 2008 Sep 25.

Abstract

Background: The T(peak)T(end) (T(p)T(e)) interval is believed to reflect the transmural dispersion of repolarization. Accordingly, it should be a risk factor in long QT syndrome (LQTS). The aim of the study was to determine the effect of genotype on T(p)T(e) interval and test whether it was related to the occurrence of syncope.

Methods: Electrocardiograms were taken in 95 patients with LQTS drawn from the Danish long QT registry (44 patients with KvLQT1, 43 with HERG, and 8 with SCN5A mutations) and manually evaluated for the QT, QT(peak), and RR interval.

Results and conclusion: (1) T(p)T(e) cannot be used to distinguish symptomatic from asymptomatic patients with LQTS; (2) HERG patients have longer T(p)T(e) than KvLQT1 patients; and (3) there is no need to heart rate-correct T(p)T(e) intervals in patients with LQTS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Comorbidity
  • Denmark / epidemiology
  • Diagnosis, Computer-Assisted / methods*
  • Electrocardiography / methods*
  • Electrocardiography / statistics & numerical data*
  • Female
  • Humans
  • Incidence
  • Long QT Syndrome / diagnosis*
  • Long QT Syndrome / epidemiology*
  • Male
  • Reproducibility of Results
  • Risk Assessment / methods*
  • Risk Factors
  • Sensitivity and Specificity
  • Syncope / diagnosis*
  • Syncope / epidemiology*