Plexiform angiomyxoid myofibroblastic tumour: differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol. 2008 Oct;61(10):1136-7. doi: 10.1136/jcp.2008.059162.

Abstract

Mesenchymal tumours other than gastrointestinal stromal tumours are rare in the stomach. Nevertheless it is important to incorporate them into the differential diagnosis. Plexiform angiomyxoid myofibroblastic tumour is a recently described new entity of a presumably benign mesenchymal gastric tumour. This report presents what is believed to be the third case of this tumour. The tumour is characterised by bland spindle cells in a plexiform pattern, a mucinous extracellular matrix and a network of thin blood vessels. These findings are completely in line with the two previous reported cases. There was a strong positivity for alpha-smooth muscle actin and a low proliferation index (<2%). The tumour had no C-KIT or CD34 expression and no mutation in the C-KIT and PDFGRalpha genes. Plexiform angiomyxoid myofibroblastic tumour may present a new mesenchymal tumour entity in the stomach.

Publication types

  • Case Reports
  • Review

MeSH terms

  • DNA Mutational Analysis
  • Diagnosis, Differential
  • Female
  • Gastrointestinal Stromal Tumors / pathology*
  • Humans
  • Immunohistochemistry
  • Mesenchymoma / pathology*
  • Mesenchymoma / surgery
  • Middle Aged
  • Myofibroma / pathology
  • Myxoma / pathology
  • Stomach Neoplasms / pathology*
  • Stomach Neoplasms / surgery