Diazoniapolycyclic ions inhibit the activity of topoisomerase I and the growth of certain tumor cell lines

ChemMedChem. 2008 Nov;3(11):1671-6. doi: 10.1002/cmdc.200800186.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Chemistry, Pharmaceutical / methods
  • DNA / chemistry
  • DNA Topoisomerases, Type I / chemistry
  • Drug Design
  • Drug Screening Assays, Antitumor
  • HL-60 Cells
  • Humans
  • Intercalating Agents / pharmacology
  • Ions*
  • Jurkat Cells
  • K562 Cells
  • Models, Chemical
  • Nitrogen / chemistry
  • Thermodynamics
  • Topoisomerase I Inhibitors*

Substances

  • Intercalating Agents
  • Ions
  • Topoisomerase I Inhibitors
  • DNA
  • DNA Topoisomerases, Type I
  • Nitrogen