Synthesis of anthracene and azaanthracene fluorophores via [2+2+2] cyclotrimerization reactions

Org Lett. 2008 Oct 16;10(20):4661-4. doi: 10.1021/ol8019549. Epub 2008 Sep 25.

Abstract

A highly convergent [2+2+2] cyclotrimerization approach to anthracenes and 2-azaanthracenes has been developed. It allows for the facile introduction of the anthracene moiety on alkyne and nitrile bearing molecules and the rapid construction of compound arrays. This is showcased in the assembly of a collection of fluorophores and their photochemical evaluation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthracenes / chemical synthesis*
  • Anthracenes / chemistry
  • Aza Compounds / chemical synthesis*
  • Aza Compounds / chemistry
  • Benzene / chemistry
  • Cell Line
  • Cyclization
  • Fluorescent Dyes / chemical synthesis*
  • Fluorescent Dyes / chemistry
  • Humans
  • Molecular Structure
  • Pyridines / chemistry

Substances

  • Anthracenes
  • Aza Compounds
  • Fluorescent Dyes
  • Pyridines
  • anthracene
  • Benzene