[Hepatocellular carcinoma with lymphoid stroma: report of two cases]

Korean J Hepatol. 2008 Sep;14(3):394-8. doi: 10.3350/kjhep.2008.14.3.394.
[Article in Korean]

Abstract

We report two cases of hepatocellular carcinoma with prominent lymphocytic infiltration, which has been described as a subtype of hepatocellular carcinoma with good prognosis. One case showed lymphoid follicles and dense lymphocytic infiltrates within the tumor and its periphery, and the other case showed marked lymphocytic infiltration in the cancerous tissue. Piecemeal necrosis of cancer cells and atypical reactive changes were evident. The two cases were seronegative for hepatitis B surface antigen, antibody to hepatitis C virus, and Epstein-Barr virus DNA. One of the cases showed Clonorchis infestation. The prognostic significance of lymphocytic stroma in hepatocellular carcinoma requires further investigation.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Animals
  • Carcinoma, Hepatocellular / diagnosis*
  • Carcinoma, Hepatocellular / pathology
  • Clonorchiasis / diagnosis
  • Clonorchiasis / parasitology
  • Clonorchis sinensis
  • Diagnosis, Differential
  • Female
  • Humans
  • Liver Neoplasms / diagnosis*
  • Liver Neoplasms / pathology
  • Lymphocytes, Tumor-Infiltrating / pathology*
  • Male
  • Middle Aged
  • Tomography, X-Ray Computed