Site-specific self-cleavage of G-quadruplexes formed by human telemetric repeats

Xinming Li; Magdeline Tao Tao Ng; Yifan Wang; Tianyan Zhou; Sock Teng Chua; Weixing Yuan; Tianhu Li

doi:10.1016/j.bmcl.2008.09.001

Site-specific self-cleavage of G-quadruplexes formed by human telemetric repeats

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5576-80. doi: 10.1016/j.bmcl.2008.09.001. Epub 2008 Sep 5.

Authors

Xinming Li¹, Magdeline Tao Tao Ng, Yifan Wang, Tianyan Zhou, Sock Teng Chua, Weixing Yuan, Tianhu Li

Affiliation

¹ Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, SPMS-CBC-04-21, Singapore 637616, Singapore.

PMID: 18812258
DOI: 10.1016/j.bmcl.2008.09.001

Abstract

It is demonstrated in our investigations that certain G-quadruplex structures formed by human telomeric repeats could perform self-cleaving actions. Our further studies verify that these reactions are site-specific and undergo hydrolytic pathways.

MeSH terms

Base Pair Mismatch
Base Sequence
DNA / chemistry
G-Quadruplexes*
Humans
Hydrolysis
Models, Molecular
Molecular Sequence Data
Nucleic Acid Conformation
Nucleic Acid Heteroduplexes / chemistry
Oligonucleotides / chemistry
Phosphates / chemistry
Telomere / ultrastructure*
Time Factors

Substances

Nucleic Acid Heteroduplexes
Oligonucleotides
Phosphates
DNA