Abstract
Piperacillin-tazobactam was administered as a single dose (4.5 g intravenous) to five patients with stabilized external pancreatic fistula. The penetration into pancreatic juice was prompt, and inhibitory concentrations were achieved and maintained for different periods (0.5 to 6 h) according to bacterial susceptibility and patients' characteristics. Piperacillin and tazobactam showed superimposable pharmacokinetics in both serum and pancreatic juice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Ampulla of Vater / surgery
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / blood
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Anti-Bacterial Agents / pharmacokinetics*
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Bacterial Infections / drug therapy
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Bacterial Infections / metabolism
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Common Bile Duct Neoplasms / surgery
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Female
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Humans
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Male
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Middle Aged
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Pancreatic Diseases / drug therapy
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Pancreatic Diseases / metabolism
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Pancreatic Juice / metabolism*
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Pancreatic Neoplasms / surgery
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Pancreaticoduodenectomy
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Penicillanic Acid / administration & dosage
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Penicillanic Acid / analogs & derivatives
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Penicillanic Acid / blood
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Penicillanic Acid / pharmacokinetics
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Piperacillin / administration & dosage
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Piperacillin / blood
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Piperacillin / pharmacokinetics
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Piperacillin, Tazobactam Drug Combination
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beta-Lactamase Inhibitors
Substances
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Anti-Bacterial Agents
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beta-Lactamase Inhibitors
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Piperacillin, Tazobactam Drug Combination
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Penicillanic Acid
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Piperacillin