Abstract
Tet 42, a novel tetracycline resistance determinant from deep subsurface bacteria, was characterized and found to have a 30% sequence similarity to TetA(Z). The protein is a putative efflux pump that shares characteristics with previously characterized pumps, including a divergently transcribed TetR repressor, a conserved GxxSDRxGRR motif, and transmembrane domains.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Sequence
-
Anti-Bacterial Agents / pharmacology
-
Antiporters / chemistry
-
Antiporters / genetics*
-
Bacteria / classification
-
Bacteria / drug effects
-
Bacteria / genetics
-
Bacteria / isolation & purification*
-
Bacterial Proteins / chemistry
-
Bacterial Proteins / genetics*
-
Base Sequence
-
DNA, Bacterial / analysis
-
DNA, Bacterial / isolation & purification
-
Geologic Sediments / microbiology*
-
Microbial Sensitivity Tests
-
Molecular Sequence Data
-
Phylogeny
-
RNA, Ribosomal, 16S / genetics
-
Tetracycline / pharmacology
-
Tetracycline Resistance / genetics*
Substances
-
Anti-Bacterial Agents
-
Antiporters
-
Bacterial Proteins
-
DNA, Bacterial
-
RNA, Ribosomal, 16S
-
tetA protein, Bacteria
-
Tetracycline