RAPping production of type I interferon in pDCs through mTOR

Nat Immunol. 2008 Oct;9(10):1097-9. doi: 10.1038/ni1008-1097.

Abstract

The production of type I interferon -- the first line of defense against virus infection and critical for innate immunity -- in plasmacytoid dendritic cells relies on the mammalian target of rapamycin.

Publication types

  • Review

MeSH terms

  • Animals
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Humans
  • Interferon Type I / biosynthesis*
  • Protein Kinases / immunology*
  • Signal Transduction / immunology*
  • TOR Serine-Threonine Kinases

Substances

  • Interferon Type I
  • Protein Kinases
  • MTOR protein, human
  • TOR Serine-Threonine Kinases