Abstract
The production of type I interferon -- the first line of defense against virus infection and critical for innate immunity -- in plasmacytoid dendritic cells relies on the mammalian target of rapamycin.
MeSH terms
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Animals
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Dendritic Cells / immunology*
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Dendritic Cells / metabolism
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Humans
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Interferon Type I / biosynthesis*
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Protein Kinases / immunology*
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Signal Transduction / immunology*
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TOR Serine-Threonine Kinases
Substances
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Interferon Type I
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Protein Kinases
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MTOR protein, human
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TOR Serine-Threonine Kinases