Abstract
Biologically active natural products often contain particularly challenging structural features and functionalities in terms of synthesis. Perhaps the greatest difficulties are those caused by issues of stereochemistry. A useful strategy for synthesizing such molecules is to devise methods of bond formation that provide opportunities for using enantioselective catalysis. In using this tactic, the desire for a particular target structure ultimately drives the development of catalytic methods. New enantioselective catalytic methods contribute to a greater fundamental understanding of how bonds can be constructed and lead to valuable synthetic technologies that are useful for a variety of applications.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Biological Products / chemical synthesis*
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Biological Products / chemistry*
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Carbazoles / chemical synthesis
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Carbazoles / chemistry
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Catalysis
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Diterpenes / chemical synthesis
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Diterpenes / chemistry
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Indans / chemical synthesis
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Indans / chemistry
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Indole Alkaloids / chemical synthesis
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Indole Alkaloids / chemistry
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Indolizines / chemical synthesis
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Indolizines / chemistry
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Lactams / chemical synthesis
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Lactams / chemistry
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Pyrazines / chemical synthesis
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Pyrazines / chemistry
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Sitagliptin Phosphate
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Spiro Compounds / chemical synthesis
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Spiro Compounds / chemistry
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Triazoles / chemical synthesis
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Triazoles / chemistry
Substances
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Biological Products
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Carbazoles
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Diterpenes
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Indans
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Indole Alkaloids
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Indolizines
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Lactams
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Pyrazines
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Spiro Compounds
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Triazoles
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cyanthiwigin F
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fluvirucinine A1
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minfiensine
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flustramine B
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indacrinone
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Sitagliptin Phosphate
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marcfortine B