Objective: To prepare esomeprazole zinc solid dispersion (EZSD) to improve its dissolution in vitro.
Methods: EZ solid dispersions were prepared by solvent method using PVP K30 and PEG 6000 as carriers. The in vitro dissolution of the EZ solid dispersions enteric capsules was analyzed. The existence status of EZ in the carrier was determined by differential scanning calorimeter (DSC).
Results: The dissolution of EZ increased first and then decreased with the increase of the ratio of carries. The dissolution of the solid dispersions with PEG 6000 as carrier was faster than that with PVP K30 as carrier. The EZ was amorphously dispersed in the solid dispersion.
Conclusion: The in vitro dissolution rate of EZ is significantly improved by the solid dispersion.