Abstract
Recent work on the regulation ofprokaryotic growth and development by two-component systems (TCS) has revealed unsuspected levels of complexity. In the dimorphic freshwater bacterium Caulobacter crescentus, TCS provide stringent temporal and spatial control of cellular development and cell-cycle progression. While the environmental signals modulating TCS regulatory networks are largely unknown, the components of the network and their interactions with each other are increasingly well-defined. Here, we present an overview of TCS regulation of cell-cycle control in C. crescentus.
MeSH terms
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Bacterial Proteins / genetics
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Bacterial Proteins / physiology
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Caulobacter crescentus / cytology*
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Caulobacter crescentus / genetics
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Caulobacter crescentus / metabolism*
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Cell Cycle / physiology*
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / physiology
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / physiology
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Genes, Bacterial
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Histidine Kinase
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Models, Biological
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Peptide Hydrolases / metabolism
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Phosphorylation
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Protein Kinases / metabolism
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Signal Transduction / physiology*
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Transcription Factors / genetics
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Transcription Factors / physiology
Substances
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Bacterial Proteins
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Cell Cycle Proteins
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CtrA protein, Caulobacter
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DNA-Binding Proteins
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DnaA protein, Bacteria
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Transcription Factors
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Protein Kinases
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Histidine Kinase
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Peptide Hydrolases