Abstract
The treatment of concurrent HIV and tuberculosis (TB) in children <3 years of age has not been well-studied and is complicated by potential drug-drug interactions. The recommended antiretroviral therapy (ART) in coinfected children in South Africa consists of full-strength ritonavir, lamivudine and stavudine. We report on a child initiated on this regimen, during concurrent TB treatment, who promptly developed an adverse reaction, virologic failure and dual-class antiretroviral drug resistance, compromising subsequent salvage ART.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
MeSH terms
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Anti-HIV Agents / pharmacology*
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Antiretroviral Therapy, Highly Active
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Antitubercular Agents / therapeutic use*
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Drug Resistance, Viral
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Drug Therapy, Combination
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HIV Infections / complications
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HIV Infections / drug therapy*
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HIV Infections / virology*
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HIV-1 / drug effects*
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HIV-1 / genetics
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Humans
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Infant
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Infant, Newborn
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Male
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RNA, Viral
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South Africa
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Treatment Outcome
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Tuberculosis / complications
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Tuberculosis / drug therapy*
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Tuberculosis / virology
Substances
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Anti-HIV Agents
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Antitubercular Agents
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RNA, Viral