Abstract
Cultures of the ascomycete Dasyscyphus niveus have yielded two new tetracyclic dasyscyphin-type terpenoids (1 and 2), and their structures were elucidated by NMR spectroscopy and X-ray crystallography. The absolute configuration of dasyscyphin D (1) was determined by synthesis and NMR spectroscopy of diastereomeric MTPA esters. Both compounds inhibited the germination of conidia of Magnaporthe grisea at 25 microg/mL.
MeSH terms
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Ascomycota / chemistry*
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Crystallography, X-Ray
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Diterpenes / chemistry*
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Fagus / microbiology
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Female
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Germany
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Humans
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Magnaporthe / drug effects
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Microbial Sensitivity Tests
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
Substances
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Antifungal Agents
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Diterpenes
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dasyscyphin D
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dasyscyphin E