Abstract
Structurally related to the known CK2 inhibitors, 2,6-disubstituted pyrazine and 4,6-disubstituted pyrimidine derivatives were synthesized and their inhibitory activities toward CK2alpha and CK2alpha' were evaluated. Structure-activity relationship study has revealed that several pyrazine derivatives bearing a (pyrrol-3-yl)acetic acid and a monosubstituted aniline possess potent inhibitory activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Casein Kinase II / antagonists & inhibitors*
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology*
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Indicators and Reagents
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Pyrazines / chemical synthesis*
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Pyrazines / pharmacology*
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Pyrimidines / chemical synthesis*
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Pyrimidines / pharmacology*
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Structure-Activity Relationship
Substances
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Enzyme Inhibitors
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Indicators and Reagents
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Pyrazines
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Pyrimidines
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Casein Kinase II