Direct, facile synthesis of N-acyl-alpha-amino amides from alpha-keto esters and ammonia

Rukundo Ntaganda; Tamara Milovic; Jorge Tiburcio; Avinash N Thadani

doi:10.1039/b808302a

Direct, facile synthesis of N-acyl-alpha-amino amides from alpha-keto esters and ammonia

Chem Commun (Camb). 2008 Sep 14:(34):4052-4. doi: 10.1039/b808302a. Epub 2008 Jul 23.

Authors

Rukundo Ntaganda¹, Tamara Milovic, Jorge Tiburcio, Avinash N Thadani

Affiliation

¹ Department of Chemistry & Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario, Canada N9B 3P4.

PMID: 18758623
DOI: 10.1039/b808302a

Abstract

N-acyl-alpha-amino amides were prepared, without the necessity of chromatographic purification, in a single step by heating the corresponding alpha-keto ester in methanolic ammonia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amides / chemical synthesis*
Aminoacylation
Ammonia / chemistry*
Esters / chemistry*
Hot Temperature
Keto Acids / chemistry*
Models, Chemical

Substances

Amides
Esters
Keto Acids
Ammonia