Abstract
Chemical investigations on the sea whip gorgonian coral Junceella juncea have led to the isolation of five new 8-hydroxybriarane diterpenoids, junceols D-H (1-5). The structures of briaranes 1-5 were determined on the basis of spectroscopic methods and the methylenecyclohexane rings were found to exist in boat form in these new diterpenoids. Junceols D (1) and F-H (3-5) exhibited cytotoxicity toward CCRF-CEM and DLD-1 tumor cells and junceols E-H (2-5) displayed weak inhibitory effects on superoxide anion generation by human neutrophils.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Antioxidants / isolation & purification*
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Antioxidants / pharmacology*
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Cell Survival
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Heterocyclic Compounds, 3-Ring / isolation & purification*
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Heterocyclic Compounds, 3-Ring / pharmacology*
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Humans
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Lactones / isolation & purification*
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Lactones / pharmacology*
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Conformation
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Neutrophils / drug effects
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Neutrophils / metabolism
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Spectrometry, Mass, Electrospray Ionization
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Stereoisomerism
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Superoxides / antagonists & inhibitors
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Superoxides / metabolism
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Tetrazolium Salts
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Thiazoles
Substances
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Antioxidants
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Heterocyclic Compounds, 3-Ring
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Lactones
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Tetrazolium Salts
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Thiazoles
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Superoxides
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thiazolyl blue