Abstract
C3-Substituted-4-azaindoles were synthesized from pyridylacetonitriles in a two-step sequence allowing the easy introduction of a range of substituents. This strategy permits the rapid synthesis of 4-azamelatonin and a protected 4-azatryptophan.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylation
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Cyclization
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Indoles / chemical synthesis*
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Indoles / chemistry
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Melatonin / analogs & derivatives*
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Melatonin / chemical synthesis
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Melatonin / chemistry
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Molecular Structure
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Stereoisomerism
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Tryptophan / analogs & derivatives*
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Tryptophan / chemical synthesis
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Tryptophan / chemistry
Substances
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4-azaindole
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4-azamelatonin
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4-azatryptophan
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Indoles
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Tryptophan
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Melatonin