Gram-negative bacterial lipopolysaccharide retention by a positively charged new-generation filter

Appl Environ Microbiol. 2008 Oct;74(20):6470-2. doi: 10.1128/AEM.00552-08. Epub 2008 Aug 22.

Abstract

Removing endotoxins is an important target in the pharmaceutical industry and in clinical practice. A filter introduced into an intravenous line prevents microbiological contamination, but to date no filters have retained bacterial endotoxins. In our study, we assayed a new-generation filter which is able to capture endotoxins from solutions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Endotoxins / isolation & purification*
  • Filtration / methods*
  • Gram-Negative Bacteria / chemistry*
  • Humans
  • Limulus Test
  • Lipopolysaccharides / isolation & purification*
  • Water Purification / methods*

Substances

  • Endotoxins
  • Lipopolysaccharides