Regioselective synthesis and antimicrobial screening of novel ketocarbazolodispiropyrrolidine derivatives

Govindasami Periyasami; Raghavachary Raghunathan; Gangadharan Surendiran; Narayanasamy Mathivanan

doi:10.1016/j.ejmech.2008.07.009

Regioselective synthesis and antimicrobial screening of novel ketocarbazolodispiropyrrolidine derivatives

Eur J Med Chem. 2009 Mar;44(3):959-66. doi: 10.1016/j.ejmech.2008.07.009. Epub 2008 Jul 18.

Authors

Govindasami Periyasami¹, Raghavachary Raghunathan, Gangadharan Surendiran, Narayanasamy Mathivanan

Affiliation

¹ Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, Tamil Nadu, India.

PMID: 18722036
DOI: 10.1016/j.ejmech.2008.07.009

Abstract

A series of novel dispiropyrrolidine derivatives have been synthesized through 1,3-dipolar cycloaddition reaction of azomethine ylide generated from sarcosin and di/tri ketone with the dipolarophile (E)-2-arylidine-1-keto-carbazoles. The cycloadducts ketocarbazalo spiro N-methyl pyrrolidines showed the most interesting antimicrobial activity at lower concentration.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Microbial Sensitivity Tests
Models, Molecular
Proteus vulgaris / drug effects
Pyrrolidines / chemical synthesis*
Pyrrolidines / chemistry
Pyrrolidines / pharmacology*
Salmonella typhi / drug effects
Spectrometry, Mass, Electrospray Ionization
Spectroscopy, Fourier Transform Infrared
Staphylococcus aureus / drug effects

Substances

Anti-Bacterial Agents
Pyrrolidines