This study examined gender differences in the relationships of actual and virtual social support to Internet addiction mediated through depressive symptoms among college students in Taiwan. Results revealed that in females, both actual and virtual social support directly predicted Internet addiction or were mediated through depressive symptoms. However, in males, while Internet addiction was predicted by virtual social support directly or indirectly mediated through depressive symptoms, the link of actual social support to Internet addiction was only mediated through depressive symptoms. Furthermore, in both genders, lower actual social support and higher virtual social support were associated with higher depressive symptoms.