Synthesis and antiprotozoal evaluation of new N4-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones)

Julieta Coro; Susan Little; Vanessa Yardley; Margarita Suárez; Hortensia Rodríguez; Nazario Martín; Rolando Perez-Pineiro

doi:10.1002/ardp.200800011

Synthesis and antiprotozoal evaluation of new N4-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones)

Arch Pharm (Weinheim). 2008 Nov;341(11):708-13. doi: 10.1002/ardp.200800011.

Authors

Julieta Coro¹, Susan Little, Vanessa Yardley, Margarita Suárez, Hortensia Rodríguez, Nazario Martín, Rolando Perez-Pineiro

Affiliation

¹ Laboratorio de Síntesis Orgánica, Facultad de Química, Universidad de la Habana, Habana, Cuba.

PMID: 18720341
DOI: 10.1002/ardp.200800011

Abstract

The synthesis and in-vitro antiprotozoal evaluation of novel N(4)-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thione) (bis-THTT) derivatives from N(4)-(benzyl)spermidine is disclosed. Several of the new bis-THTT have in-vitro activities against L. donovani and T. cruzi that are comparable or superior to those of currently employed protozoocidal agents.

MeSH terms

Animals
Antiprotozoal Agents / chemical synthesis*
Antiprotozoal Agents / pharmacology
Drug Evaluation, Preclinical
Leishmania donovani / drug effects
Spermidine / chemistry
Structure-Activity Relationship
Thiones / chemical synthesis*
Thiones / pharmacology
Trypanosoma cruzi / drug effects

Substances

Antiprotozoal Agents
Thiones
Spermidine