cneViewer: a database of conserved non-coding elements for studies of tissue-specific gene regulation

Bioinformatics. 2008 Oct 15;24(20):2418-9. doi: 10.1093/bioinformatics/btn443. Epub 2008 Aug 20.

Abstract

There are thousands of strongly conserved non-coding elements (CNEs) in vertebrate genomes, and their functions remain largely unknown. However, without biologically relevant criteria for prioritizing them, selecting a particular CNE sequences to study can be haphazard. To address this problem, we present cneViewer-a database and webtool that systematizes information on conserved non-coding DNA elements in zebrafish. A key feature here is the ability to search for CNEs that may be relevant to tissue-specific gene regulation, based on known developmental expression patterns of nearby genes. cneViewer provides this and other organizing features that significantly facilitate experimental design and CNE analysis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Base Sequence
  • Computational Biology / methods*
  • Conserved Sequence
  • DNA / chemistry
  • Databases, Genetic*
  • Gene Expression Regulation*
  • Humans
  • Internet
  • Molecular Sequence Data
  • Regulatory Sequences, Nucleic Acid*
  • Software
  • Zebrafish / genetics*

Substances

  • DNA