Stress cardiomyopathy or Tako-Tsubo Syndrome (TTS) clinically manifests with sudden chest pain and/or dyspnea, and is generally triggered by emotional or physical stress. Electrocardiographic (ECG) changes are similar to acute myocardial infarction with ST-elevation, but coronarography shows no significant pathomorphological changes of coronary arteries. Ventriculography and echocardiography show reversible akinesis and ballooning of the left ventricle apex with reduced ejection fraction. Like as it is with TTS, similar ECG changes are extensively reported in patients with intracerebral bleeding. We reported the case of a 52-year-old female patient who was clinically presented with stress cardiomyopathy with ST-segment elevation of the anterolateral location complicated by a secondary massive intracranial bleeding. Many cases of TTS or ECG changes in intracranial bleeding were described separately, but to our knowledge, this is the first report where both events developed in the same patient with the fatal outcome.