Comparison of protocols efficacy in poor responders: differences in oocytes/embryos competence with different protocols, a retrospective study

Massimo Manno; Francesco Tomei; Marta Cervi; Cristina Favretti; Valter Adamo

doi:10.1016/j.fertnstert.2008.06.001

Comparison of protocols efficacy in poor responders: differences in oocytes/embryos competence with different protocols, a retrospective study

Fertil Steril. 2009 Apr;91(4 Suppl):1431-3. doi: 10.1016/j.fertnstert.2008.06.001. Epub 2008 Aug 15.

Authors

Massimo Manno¹, Francesco Tomei, Marta Cervi, Cristina Favretti, Valter Adamo

Affiliation

¹ Maternal-Pediatric Department, Pordenone Hospital, Pathophysiology Unit of Human Reproduction and Sperm Bank, Pordenone, Italy. massimo.manno@aopn.fvg.it

PMID: 18706554
DOI: 10.1016/j.fertnstert.2008.06.001

Abstract

At present, there is no agreement on poor ovarian response definition, and no definitive evidence that this prognosis can be changed by a specific protocol. Our data suggest that a flare-up protocol with a depot gonadotropin-releasing hormone (GnRH) agonist formulation gives higher total pregnancy and implantation rates than a GnRH antagonist, possibly by improving oocyte/embryo competence.

Publication types

Comparative Study

MeSH terms

Adult
Chorionic Gonadotropin / pharmacology
Clinical Protocols*
Dose-Response Relationship, Drug
Embryo Transfer
Embryonic Development / physiology*
Female
Gonadotropin-Releasing Hormone / agonists*
Gonadotropin-Releasing Hormone / antagonists & inhibitors*
Humans
Luteolytic Agents / pharmacology
Oocytes / drug effects
Oocytes / physiology*
Ovulation Induction / methods*
Pregnancy
Pregnancy Rate
Retrospective Studies
Sperm Injections, Intracytoplasmic
Triptorelin Pamoate / pharmacology

Substances

Chorionic Gonadotropin
Luteolytic Agents
Triptorelin Pamoate
Gonadotropin-Releasing Hormone