Dynamics of the mucosa-associated flora in ulcerative colitis patients during remission and clinical relapse

J Clin Microbiol. 2008 Oct;46(10):3510-3. doi: 10.1128/JCM.01512-08. Epub 2008 Aug 13.

Abstract

The colonic mucosa-associated flora (MAF) in patients with active ulcerative colitis (UC) (n = 13) was investigated by examining 16S rRNA gene signatures during remission and relapse against levels for controls (n = 5). Baseline reduction, temporal instability, and decrease of bacterial richness toward relapse were observed for UC patients, whereas the MAF for controls was stable over time.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biodiversity*
  • Colitis, Ulcerative / microbiology*
  • Colitis, Ulcerative / prevention & control
  • Colon / microbiology*
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • DNA, Ribosomal / chemistry
  • DNA, Ribosomal / genetics
  • Female
  • Humans
  • Intestinal Mucosa / microbiology*
  • Male
  • Middle Aged
  • Phylogeny
  • RNA, Ribosomal, 16S / genetics
  • Recurrence
  • Sequence Analysis, DNA

Substances

  • DNA, Bacterial
  • DNA, Ribosomal
  • RNA, Ribosomal, 16S