Abstract
Blood islands are conglomerations of prevascular stem cells that form during vasculogenesis, a function critical to early vascular and hematopoietic development. In this paper, a model of blood island formation is proposed employing the approach of classical enzyme kinetics. Deterministic simulations of the model show the formation of blood island-like structures. These are compared to murine blood islands.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Blood Vessels / cytology
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Blood Vessels / embryology*
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Embryonic Stem Cells / cytology*
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Enzymes / metabolism
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GATA2 Transcription Factor / physiology
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Hematopoiesis
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Kinetics
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Mathematics*
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Mesoderm / cytology
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Mesoderm / embryology
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Mice
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Models, Biological*
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Pluripotent Stem Cells / cytology
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Transforming Growth Factor beta1 / physiology
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Vascular Endothelial Growth Factor A / physiology
Substances
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Enzymes
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GATA2 Transcription Factor
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Gata2 protein, mouse
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Transforming Growth Factor beta1
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Vascular Endothelial Growth Factor A
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vascular endothelial growth factor A, mouse