An enzyme kinetic model of blood island formation

Math Med Biol. 2008 Sep;25(3):233-45. doi: 10.1093/imammb/dqn016. Epub 2008 Aug 11.

Abstract

Blood islands are conglomerations of prevascular stem cells that form during vasculogenesis, a function critical to early vascular and hematopoietic development. In this paper, a model of blood island formation is proposed employing the approach of classical enzyme kinetics. Deterministic simulations of the model show the formation of blood island-like structures. These are compared to murine blood islands.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Blood Vessels / cytology
  • Blood Vessels / embryology*
  • Embryonic Stem Cells / cytology*
  • Enzymes / metabolism
  • GATA2 Transcription Factor / physiology
  • Hematopoiesis
  • Kinetics
  • Mathematics*
  • Mesoderm / cytology
  • Mesoderm / embryology
  • Mice
  • Models, Biological*
  • Pluripotent Stem Cells / cytology
  • Transforming Growth Factor beta1 / physiology
  • Vascular Endothelial Growth Factor A / physiology

Substances

  • Enzymes
  • GATA2 Transcription Factor
  • Gata2 protein, mouse
  • Transforming Growth Factor beta1
  • Vascular Endothelial Growth Factor A
  • vascular endothelial growth factor A, mouse