Abstract
We report two cases of radiation-induced sarcoma after chemoradiation therapy in nasopharyngeal carcinoma. Case 1: A 40-year-old man developed a malignant peripheral nerve sheath tumor (MPNST) in the posterior floor of the nasal cavity 10 years after treatment for nasopharyngeal cancer. Case 2: A 64 year-old man developed a malignant fibrous histiocytoma (MFH) of the lower gum 10 years after treatment of nasopharyngeal cancer. Despite radical surgery, the man with MPNST had a recurrent tumor and died of the disease.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adult
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Carcinoma, Squamous Cell / therapy
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Cisplatin / administration & dosage
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Cisplatin / therapeutic use
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Combined Modality Therapy
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Fatal Outcome
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Fluorouracil / administration & dosage
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Histiocytoma, Malignant Fibrous / etiology*
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Histiocytoma, Malignant Fibrous / pathology
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Histiocytoma, Malignant Fibrous / surgery
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Humans
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Male
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Middle Aged
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Nasopharyngeal Neoplasms / etiology*
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Nasopharyngeal Neoplasms / pathology
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Nasopharyngeal Neoplasms / surgery
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Nasopharyngeal Neoplasms / therapy
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Neoplasms, Radiation-Induced / etiology*
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Neoplasms, Radiation-Induced / pathology
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Neoplasms, Radiation-Induced / surgery
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Nerve Sheath Neoplasms / etiology*
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Nerve Sheath Neoplasms / pathology
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Nerve Sheath Neoplasms / surgery
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Radiotherapy / adverse effects*
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Radiotherapy Dosage
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Treatment Outcome