XPD structure reveals its secrets

Alan R Lehmann

doi:10.1016/j.dnarep.2008.07.008

XPD structure reveals its secrets

DNA Repair (Amst). 2008 Nov 1;7(11):1912-5. doi: 10.1016/j.dnarep.2008.07.008. Epub 2008 Aug 27.

Author

Alan R Lehmann¹

Affiliation

¹ Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, UK. a.r.lehmann@sussex.ac.uk

PMID: 18692601
DOI: 10.1016/j.dnarep.2008.07.008

Abstract

The XPD protein is central to our understanding of the relationship between NER deficiencies and human disorders. Three recent papers report the crystal structures of XPD from archaea. Apart from anticipated helicase domains the structures reveal a 4FeS cluster and novel "Arch" domain. The structures help our understanding of genotype-phenotype relationships in the XPD gene.

Publication types

Review

MeSH terms

Binding Sites
Crystallography, X-Ray
Genotype
Humans
Models, Biological
Models, Genetic
Models, Molecular
Molecular Conformation
Mutation
Phenotype
Protein Binding
Protein Conformation
Protein Structure, Tertiary
Sulfolobus acidocaldarius / metabolism
Xeroderma Pigmentosum Group D Protein / genetics*
Xeroderma Pigmentosum Group D Protein / physiology*

Substances

Xeroderma Pigmentosum Group D Protein
ERCC2 protein, human