Abstract
The polyphenol quercetin has recently been found to extend lifespan and increase stress resistance in the nematode Caenorhabditis elegans. The forkhead transcription factor DAF-16 has previously been linked to these effects. However, by using a daf-16(mgDf50) mutant strain, we show that quercetin exposure leads to increased mean lifespans up to 15%. Furthermore, quercetin-treated daf-16(mgDf50) worms show an enhanced resistance to thermal and oxidative stress. Our data reveal that DAF-16 is not obligatorily required for quercetin-mediated longevity and stress resistance.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Antioxidants / pharmacology*
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Caenorhabditis elegans
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Caenorhabditis elegans Proteins / genetics*
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Caenorhabditis elegans Proteins / physiology*
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Dose-Response Relationship, Drug
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Forkhead Transcription Factors
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Gene Expression Profiling
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Longevity / drug effects
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Longevity / genetics*
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Mutation*
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Oxidative Stress
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Quercetin / pharmacology*
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Temperature
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Time Factors
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Transcription Factors / genetics*
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Transcription Factors / physiology*
Substances
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Antioxidants
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Caenorhabditis elegans Proteins
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Forkhead Transcription Factors
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Transcription Factors
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daf-16 protein, C elegans
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Quercetin