Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved?

Mech Ageing Dev. 2008 Oct;129(10):611-3. doi: 10.1016/j.mad.2008.07.001. Epub 2008 Jul 23.

Abstract

The polyphenol quercetin has recently been found to extend lifespan and increase stress resistance in the nematode Caenorhabditis elegans. The forkhead transcription factor DAF-16 has previously been linked to these effects. However, by using a daf-16(mgDf50) mutant strain, we show that quercetin exposure leads to increased mean lifespans up to 15%. Furthermore, quercetin-treated daf-16(mgDf50) worms show an enhanced resistance to thermal and oxidative stress. Our data reveal that DAF-16 is not obligatorily required for quercetin-mediated longevity and stress resistance.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antioxidants / pharmacology*
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins / genetics*
  • Caenorhabditis elegans Proteins / physiology*
  • Dose-Response Relationship, Drug
  • Forkhead Transcription Factors
  • Gene Expression Profiling
  • Longevity / drug effects
  • Longevity / genetics*
  • Mutation*
  • Oxidative Stress
  • Quercetin / pharmacology*
  • Temperature
  • Time Factors
  • Transcription Factors / genetics*
  • Transcription Factors / physiology*

Substances

  • Antioxidants
  • Caenorhabditis elegans Proteins
  • Forkhead Transcription Factors
  • Transcription Factors
  • daf-16 protein, C elegans
  • Quercetin