Combined use of vaccines and immunostimulants is emerging as one of innovative approaches in adjuvant development. The article by Sakure et al. [Sakure S, Negi VD, Mitra SK, Nandakumar KS, Chakravortty D. Vaccine with herbal adjuvant-a better cocktail to combat the infection. Vaccine 2008;26(27-28):3387-8] highlights the importance of herbal immunomodulatory drugs in such bioprospecting. The article indicates challenges in selection of herbal drugs for such bioprospecting. We suggest that ethnopharmacology in contrast to random screening approach, which will be more cost and time effective.