In vivo protein delivery to human liver-derived cells using hepatitis B virus envelope pre-S region

J Biosci Bioeng. 2008 Jul;106(1):99-102. doi: 10.1263/jbb.106.99.

Abstract

Human hepatocyte-specific delivery of green fluorescent protein was succeeded in the mouse xenograft model by fusion with hepatitis B virus surface antigen pre-S regions (pre-S(1+2)), not with each pre-S region. The entire pre-S region would be useful for human liver-specific delivery of therapeutic proteins and bio-imaging fluoroproteins in biomedical field.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Cells, Cultured
  • Drug Delivery Systems / methods*
  • Hepatitis B virus / metabolism*
  • Hepatocytes / metabolism*
  • Humans
  • Peptides / administration & dosage
  • Peptides / chemistry*
  • Viral Envelope Proteins / chemistry*
  • Viral Envelope Proteins / pharmacokinetics*

Substances

  • Peptides
  • Viral Envelope Proteins