Abstract
Human hepatocyte-specific delivery of green fluorescent protein was succeeded in the mouse xenograft model by fusion with hepatitis B virus surface antigen pre-S regions (pre-S(1+2)), not with each pre-S region. The entire pre-S region would be useful for human liver-specific delivery of therapeutic proteins and bio-imaging fluoroproteins in biomedical field.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Cell Line
-
Cells, Cultured
-
Drug Delivery Systems / methods*
-
Hepatitis B virus / metabolism*
-
Hepatocytes / metabolism*
-
Humans
-
Peptides / administration & dosage
-
Peptides / chemistry*
-
Viral Envelope Proteins / chemistry*
-
Viral Envelope Proteins / pharmacokinetics*
Substances
-
Peptides
-
Viral Envelope Proteins