Abstract
This review will discuss the structural determinants and requirements necessary for estrogen receptors alpha and beta selectivity and ligand-receptor binding affinity. In addition, strategies likely to result in the development of a pharmacophore model that account for the differences in estrogenic effects between different ligands will be discussed.
MeSH terms
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Animals
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Chemistry, Pharmaceutical / methods*
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Drug Design*
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Estrogen Receptor Modulators / pharmacology*
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Estrogen Receptor alpha / metabolism*
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Estrogens / chemistry
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Humans
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Ligands
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Models, Molecular
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Protein Conformation
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Pyridines / chemistry
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Receptors, Estrogen / metabolism*
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Software
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Structure-Activity Relationship
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Technology, Pharmaceutical / methods*
Substances
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ESR1 protein, human
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Estrogen Receptor Modulators
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Estrogen Receptor alpha
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Estrogens
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Ligands
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Pyridines
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Receptors, Estrogen