Abstract
Polyfunctionalized benzo[d]sultams 7 and 8, which contain an alpha-amino acid unit, have been synthesized from the corresponding open chain (pentafluorobenzene)sulfonamides 4 by complementary solid-liquid phase transfer catalysis (SL-PTC) and homogeneous protocols. The cyclization step proceeds through the intramolecular nucleophilic displacement of an aromatic fluorine atom.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetonitriles / chemistry
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Amino Acids / chemistry
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Carbon / chemistry*
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Catalysis
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Combinatorial Chemistry Techniques / methods*
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Cyclization
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Fluorine / chemistry
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Fluorobenzenes / chemistry*
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Hydrocarbons, Iodinated / chemistry
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Models, Chemical
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Sulfonamides / chemical synthesis*
Substances
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Acetonitriles
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Amino Acids
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Fluorobenzenes
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Hydrocarbons, Iodinated
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Sulfonamides
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beta-sultam
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Fluorine
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Carbon
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methyl iodide