Genetic association between SORL1 polymorphisms and Alzheimer's disease in a Japanese population

Dement Geriatr Cogn Disord. 2008;26(2):161-4. doi: 10.1159/000149821. Epub 2008 Aug 6.

Abstract

Background/aims: It has recently been shown that the neuronal sortilin-related receptor (SORL1) plays an important role in the pathogenesis of Alzheimer's disease (AD).

Methods: To investigate whether variations around the SORL1 gene are associated with AD, 7 single-nucleotide polymorphisms (SNPs) were genotyped using TaqMan technology with 180 AD patients and 130 age-matched controls.

Results: Our results confirmed the strong linkage disequilibrium among the 7 SNPs studied. However, our study failed to detect any association between the SNPs and AD. We could not confirm any synergetic interaction between the SNPs and apolipoprotein E in our AD patients either.

Conclusion: Further genetic studies are needed to clarify the relationship between the SORL1 gene and AD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / ethnology*
  • Alzheimer Disease / genetics*
  • Apolipoprotein E4 / genetics
  • Asian People / statistics & numerical data*
  • Female
  • Follow-Up Studies
  • Humans
  • Japan / epidemiology
  • LDL-Receptor Related Proteins / genetics*
  • Linkage Disequilibrium
  • Male
  • Membrane Transport Proteins / genetics*
  • Middle Aged
  • Polymorphism, Single Nucleotide*

Substances

  • Apolipoprotein E4
  • LDL-Receptor Related Proteins
  • Membrane Transport Proteins
  • SORL1 protein, human