Genetic modification-free reprogramming to induced pluripotent cells: fantasy or reality?

Takashi Tada

doi:10.1016/j.stem.2008.07.005

Genetic modification-free reprogramming to induced pluripotent cells: fantasy or reality?

Cell Stem Cell. 2008 Aug 7;3(2):121-2. doi: 10.1016/j.stem.2008.07.005.

Author

Takashi Tada¹

Affiliation

¹ Stem Cell Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. ttada@frontier.kyoto-u.ac.jp

PMID: 18682230
DOI: 10.1016/j.stem.2008.07.005

Abstract

Significant development in the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) has been achieved by retroviral infection of defined genes. Several recent reports, including one in this issue of Cell Stem Cell (Marson et al., 2008), have started to replace these genetic changes with specific chemical stimulation.

Publication types

Comment
Introductory Journal Article

MeSH terms

Animals
Cellular Reprogramming / genetics*
Epigenesis, Genetic / physiology*
Humans
Pluripotent Stem Cells / cytology
Pluripotent Stem Cells / metabolism*
Protein Binding
Proto-Oncogene Proteins c-myc / genetics
Proto-Oncogene Proteins c-myc / metabolism
Signal Transduction / physiology*
Wnt Proteins / genetics
Wnt Proteins / metabolism
beta Catenin / genetics
beta Catenin / metabolism

Substances

MYC protein, human
Proto-Oncogene Proteins c-myc
Wnt Proteins
beta Catenin