Abstract
The fluorescence of NABQ increases remarkably in the presence of Zn(2+) and is quenched by Hg(2+). As shown by confocal imaging, NABQ-Zn(2+) can penetrate cells, where the bound Zn(2+) is exchanged for Hg(2+). This results in the concomitant export of Hg(2+) from the cells, showing that NABQ can act as a Zn(2+) carrier and as a Hg(2+) extracting agent in living cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Benzenesulfonamides
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Cations, Divalent / chemistry
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Cell Line
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry*
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Humans
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Mercury / analysis
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Mercury / chemistry*
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Mercury / metabolism
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Quinaldines / chemical synthesis
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Quinaldines / chemistry*
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Spectrometry, Fluorescence / methods
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Sulfonamides / chemical synthesis
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Sulfonamides / chemistry
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Zinc / analysis
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Zinc / chemistry*
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Zinc / metabolism
Substances
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Cations, Divalent
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Fluorescent Dyes
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Quinaldines
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Sulfonamides
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Mercury
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Zinc