Vaccination of dogs against Echinococcus granulosus: a means to control hydatid disease?

Trends Parasitol. 2008 Sep;24(9):419-24. doi: 10.1016/j.pt.2008.05.008. Epub 2008 Aug 3.

Abstract

Hydatid disease continues to be a substantial cause of morbidity and mortality worldwide. Elimination is difficult with current control options, but reducing egg production by Echinococcus granulosus (Eg) in canines might help to reduce transmission in areas where the parasite is endemic. Recently obtained data using recombinant protein-based and live attenuated Salmonella vaccines are preliminary but encouraging and auger well for the future development of an effective dog vaccine against Eg, although much additional work is required before this becomes a reality. New approaches to control and for the prevention of hydatidosis have been described recently, and important additional gains should be expected if the efficacy of the dog vaccines is confirmed and leads to their incorporation into future control options.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Dog Diseases / prevention & control*
  • Dogs
  • Echinococcosis / prevention & control
  • Echinococcosis / veterinary*
  • Echinococcus granulosus / immunology*
  • Humans
  • Protozoan Proteins / immunology
  • Protozoan Vaccines* / immunology
  • Recombinant Proteins / immunology
  • Salmonella
  • Vaccines, Attenuated / immunology

Substances

  • Protozoan Proteins
  • Protozoan Vaccines
  • Recombinant Proteins
  • Vaccines, Attenuated