We describe a repeat aortic root replacement using a cryopreserved aortic homograft in a patient with active composite valve-graft endocarditis and an aortic root abscess. At the second surgery, infected prosthetic material was removed and surrounding tissue was radically debrided. The cryopreserved aortic homograft was positioned using the full root technique with a concomitant coronary bypass graft. The postoperative course was uneventful and the patient continues to thrive 2 years after the repeat operation.