Abstract
New derivatives of 3-amino-1,2,6-thiadiazine 1,1-dioxide have been synthesized and their antibacterial, antifungal and DHFR inhibitory activities evaluated. Their chemical structures have been established by means of analytical and NMR spectroscopic data. Among the compounds studied, the 4,4-dibromo derivative 11 showed fungistatic activity against C. albicans.
MeSH terms
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Animals
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Anti-Bacterial Agents
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology
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Bacteria / drug effects
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Candida albicans / drug effects
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Cattle
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Folic Acid Antagonists
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Liver / enzymology
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Thiadiazines / chemical synthesis*
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Thiadiazines / chemistry
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Thiadiazines / pharmacology
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Trimethoprim / analogs & derivatives*
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Trimethoprim / chemical synthesis
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Trimethoprim / pharmacology
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Folic Acid Antagonists
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Thiadiazines
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Trimethoprim