The chemical and hydroxyl radical scavenging activity changes of ginsenoside-Rb1 by heat processing

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4515-20. doi: 10.1016/j.bmcl.2008.07.056. Epub 2008 Jul 17.

Abstract

The chemical and hydroxyl radical (*OH) scavenging activity changes of ginsenoside Rb(1) (Rb(1)) by heat processing were investigated in this study. Rb(1) was changed into 20(S)-Rg(3), 20(R)-Rg(3), Rk(1), and Rg(5) by heat processing through glucosyl elimination and epimerization of carbon-20 by SN1 reaction. The glucosyl moiety, separated from Rb(1), made Maillard reaction product (MRPs) with glycine. The generations of 20(S)-Rg(3) and MRPs were related to the increased OH scavenging activity of Rb(1) by heat processing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chemistry, Pharmaceutical / methods
  • Chromatography, High Pressure Liquid
  • Electron Spin Resonance Spectroscopy
  • Free Radical Scavengers / pharmacology
  • Ginsenosides / chemistry*
  • Glucose / chemistry
  • Glycine / chemistry
  • Hot Temperature
  • Hydroxyl Radical*
  • Light
  • Maillard Reaction
  • Models, Chemical
  • Panax / chemistry
  • Plant Extracts / chemistry*
  • Superoxides

Substances

  • Free Radical Scavengers
  • Ginsenosides
  • Plant Extracts
  • Superoxides
  • Hydroxyl Radical
  • ginsenoside Rb1
  • Glucose
  • Glycine