Changes in the hormonal balance and the contents of carbohydrates, nitrogen, phosphorus, and potassium in overwintering organs of the biennial herb clary (Salvia sclarea L.) have been studied in relation to the adverse influence of environmental factors. Weather-related changes in tissue contents of cytokinins (CTK), abscisic acid (ABA), water-soluble sugars, and mineral nutrients elements have been detected in these organs. Each overwintering organ (rosette leaves, the basal part of the stem with axillary growth buds, and the storage portion of the root) is characterized by specific dynamics of the compounds tested. The role of phytohormones and carbohydrates in realization of plant adaptation potential is discussed.