Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease

Neurology. 2008 Jul 29;71(5):383; author reply 383. doi: 10.1212/01.wnl.0000324089.63164.16.
No abstract available

Publication types

  • Comment
  • Letter

MeSH terms

  • Alzheimer Disease / pathology*
  • Alzheimer Disease / physiopathology
  • Alzheimer Disease / prevention & control
  • Amyloid beta-Peptides / drug effects
  • Amyloid beta-Peptides / metabolism
  • Animals
  • Brain / drug effects*
  • Brain / metabolism
  • Brain / pathology*
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Down-Regulation / drug effects
  • Down-Regulation / physiology
  • Drug Administration Schedule
  • Early Diagnosis
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Hypercholesterolemia / complications
  • Hypercholesterolemia / drug therapy
  • Hypercholesterolemia / metabolism
  • Mice
  • Neurofibrillary Tangles / drug effects
  • Neurofibrillary Tangles / metabolism
  • Neurofibrillary Tangles / pathology
  • Neuroprotective Agents / pharmacology*
  • Neuroprotective Agents / therapeutic use
  • Plaque, Amyloid / drug effects
  • Plaque, Amyloid / metabolism
  • Plaque, Amyloid / pathology
  • Research Design

Substances

  • Amyloid beta-Peptides
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Neuroprotective Agents