Hyaluronan, CD44, and cyclooxygenase-2 in colon cancer

Connect Tissue Res. 2008;49(3):219-24. doi: 10.1080/03008200802143356.

Abstract

Carcinomas arising from colon epithelia develop or progress in a stromal microenvironment that is elevated in hyaluronan; interactions between elevated hyaluronan and the CD44 receptors on epithelial tumor cells activate an HA-receptor tyrosine kinase-mediated cell survival pathway. In this review we provide evidence that the hyaluronan-ErbB2-PI3kinase/AKT-ss-catenin-COX-2 signaling axis leads to intestinal epithelial and colon tumor cell division and proliferation. This review includes a summary of the authors work over the past years as well as citations of specific reviews related to role of hyaluronan in the pathogenesis of colon cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Colonic Neoplasms / metabolism*
  • Colonic Neoplasms / pathology
  • Cyclooxygenase 2 / metabolism*
  • Disease Progression
  • Extracellular Matrix / metabolism
  • Humans
  • Hyaluronan Receptors / metabolism*
  • Hyaluronic Acid / chemistry
  • Hyaluronic Acid / metabolism*
  • Receptor Protein-Tyrosine Kinases / metabolism*

Substances

  • Hyaluronan Receptors
  • Hyaluronic Acid
  • Cyclooxygenase 2
  • PTGS2 protein, human
  • Receptor Protein-Tyrosine Kinases

Associated data

  • PDB/E2