Based on the TM images of 1988 and 2003 as well as the land-use change survey data in 2004, the vegetation change in Shenzhen City was assessed by a NDVI (normalized difference vegetation index) change classification method, and the impacts from natural and social constraining factors were analyzed. The results showed that as a whole, the rapid urbanization in 1988-2003 had less impact on the vegetation cover in the City, but in its plain areas with low altitude, the vegetation cover degraded more obviously. The main causes of the localized ecological degradation were the invasion of built-ups to woods and orchards, land transformation from woods to orchards at the altitude of above 100 m, and low percentage of green land in some built-ups areas. In the future, the protection and construction of vegetation in Shenzhen should focus on strengthening the protection and restoration of remnant woods, trying to avoid the built-ups' expansion to woods and orchards where are better vegetation-covered, rectifying the unreasonable orchard constructions at the altitude of above 100 m, and consolidating the greenbelt construction inside the built-ups. It was considered that the NDVI change classification method could work well in efficiently uncovering the trend of macroscale vegetation change, and avoiding the effect of random noise in data.